| Identification | Back Directory | [Name]
MMP INHIBITOR I | [CAS]
124168-73-6 | [Synonyms]
FN-439
MMP INHIBITOR 1
MMP INHIBITOR I
METALLOPROTEASE INHIBITOR 1
4-ABZ-GLY-PRO-D-LEU-D-ALA-NHOH
H-4-ABZ-GLY-PRO-D-LEU-D-ALA-NHOH
MATRIX METALLOPROTEINASE INHIBITOR I
P-aminobenzoyl-gly-pro-D-leu-D-ala*hydroxamic aci
4-aminobenzoyl-gly-pro-d-leu-d-ala hydroxamic acid
P-AMINOBENZOYL-GLY-PRO-D-LEU-D-ALA HYDROXAMIC ACID
4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt
4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid >=95% (HPLC)
D-AlaninaMide, N-(4-aMinobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy- | [Molecular Formula]
C23H34N6O6 | [MDL Number]
MFCD00237459 | [MOL File]
124168-73-6.mol | [Molecular Weight]
490.55 |
| Chemical Properties | Back Directory | [density ]
1.288±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
H2O: 1 mg/mL | [form ]
solid | [pka]
9.34±0.40(Predicted) | [color ]
white | [Water Solubility ]
water: 1mg/mL |
| Hazard Information | Back Directory | [Uses]
FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation[1][2]. | [Biological Activity]
Collagenase Inhibitor | [in vivo]
FN-439 significantly decreases neutrophils and macrophages, shows extensive bone formation and active cementogenesis in the periapical region when has a combination with ofloxaci[2]. | [References]
[1] U Benbow, et al. Human breast cancer cells activate procollagenase-1 and invade type I collagen: invasion is inhibited by all-trans retinoic acid. Clin Exp Metastasis. 1999 May;17(3):231-8. DOI:10.1023/a:1006639214618
[2] H Anan, et al. Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions. J Endod. 1996 Dec;22(12):668-73. DOI:10.1016/S0099-2399(96)80061-6 |
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