| Identification | Back Directory | [Name]
N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-Trifluoroacetate | [CAS]
1239262-52-2 | [Synonyms]
CS-225
Tubastain A
Tubastatin A
TUBASTANTIN A
TubaststinA HCl
Tubastatin A_HCl
Tubastatin A TFA
Tubastatin TFA salt
Tubastatin A CF3COOH
Tubastatin A Trifluoroacetate
Tubastatin A 2,2,2-trifluoroacetate
Tubastatin A Trifluoroacetic Acid Salt
N-Hydroxy-4-((2-Methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)Methyl)benzaMide 2,2,2-trifluoroacetate
N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-Trifluoroacetate | [Molecular Formula]
C22H22F3N3O4 | [MDL Number]
MFCD18071463 | [MOL File]
1239262-52-2.mol | [Molecular Weight]
431.408 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: 0.2 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Uses]
Neuroprotective HDAC6 inhibitor. | [in vivo]
Daily treatment of Tubastatin A at 0.5 mg/kg inhibits HDAC6 to promote Tregs suppressive activity in mouse models of inflammation and autoimmunity, including multiple forms of experimental colitis and fully major histocompatibility complex (MHC)-incompatible cardiac allograft rejection[2]. | [storage]
Store at -20°C |
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