| Identification | Back Directory | [Name]
NS-398 | [CAS]
123653-11-2 | [Synonyms]
NS NS
NS-398
CS-2231
NS-398 98%
Taisho NS 398
NS-398 (NS 398
NS-398 USP/EP/BP
NS-398 - CAS 123653-11-2 - Calbiochem
N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide
N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]-METHANESULFONAMIDE
Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]-
NS 398; NS398; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANE SULFONAMIDE | [Molecular Formula]
C13H18N2O5S | [MDL Number]
MFCD00882995 | [MOL File]
123653-11-2.mol | [Molecular Weight]
314.36 |
| Chemical Properties | Back Directory | [Melting point ]
124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) | [Boiling point ]
490.6±55.0 °C(Predicted) | [density ]
1.377±0.06 g/cm3(Predicted) | [RTECS ]
PB0473500 | [storage temp. ]
Store at RT | [solubility ]
DMSO: >5 mg/mL
| [form ]
solid
| [pka]
6.33±0.10(Predicted) | [color ]
off-white
|
| Hazard Information | Back Directory | [Description]
NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC50 values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively. | [Uses]
Cyclooxygenase inhibitor. Selectively inhibits PGH synthase-2 (IC50=1 μM) with no inhibition of PGH synthase-1 at concentrations up to 100 μM. Protects neuronal cultures from LPS-induced neurotoxicity. | [Definition]
ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2. | [Biological Activity]
Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo . | [storage]
Store at -20℃ | [References]
[1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46. |
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