| Chemical Properties | Back Directory | [Boiling point ]
814.9±75.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
8.77±0.40(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Description]
DS-5272 is a potent and orally active p53-MDM2 interaction inhibitor. | [Uses]
DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice[1]. | [References]
[1] Miyazaki M, et al., Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor. Bioorg Med Chem. 2015 May 15;23(10):2360-7. DOI:10.1016/j.bmc.2015.03.069 |
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| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Website: |
http://www.sigmaaldrich.cn |
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