| Identification | Back Directory | [Name]
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole | [CAS]
1231930-33-8 | [Synonyms]
Abemaciclib Impurity 1
6-Bromo-4-fluoro-1-isopropyl-2-methylbenzimidazole
6-bromo-4-fluoro-2-methyl-1-propan-2-ylbenzimidazole
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole
6-bromo-4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3-benzodiazole
1H-BenziMidazole, 6-broMo-4-fluoro-2-Methyl-1-(1-Methylethyl)-
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole ISO 9001：2015 REACH | [EINECS(EC#)]
807-019-0 | [Molecular Formula]
C11H12BrFN2 | [MDL Number]
MFCD16660227 | [MOL File]
1231930-33-8.mol | [Molecular Weight]
271 |
| Chemical Properties | Back Directory | [Boiling point ]
353.4±22.0 °C(Predicted) | [density ]
1.49 | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
3.48±0.10(Predicted) | [InChI]
InChI=1S/C11H12BrFN2/c1-6(2)15-7(3)14-11-9(13)4-8(12)5-10(11)15/h4-6H,1-3H3 | [InChIKey]
SJQZRZLUEGCXFN-UHFFFAOYSA-N | [SMILES]
C1(C)N(C(C)C)C2=CC(Br)=CC(F)=C2N=1 |
| Hazard Information | Back Directory | [Uses]
6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole is a pharmaceutical intermediate. It can be used in the preparation of Abemaciclib, a kinase inhibitor for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer who have experienced disease progression following endocrine therapy and prior chemotherapy. | [Flammability and Explosibility]
Notclassified |
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