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ChemicalBook--->CAS DataBase List--->1228664-49-0

1228664-49-0

1228664-49-0 Structure

1228664-49-0 Structure
IdentificationBack Directory
[Name]

Gefitinib-d6
[CAS]

1228664-49-0
[Synonyms]

Gefitinib-d6
[2H6]-Gefitinib
Hexadeuterated gefitinib
[Molecular Formula]

C22H24ClFN4O3
[MDL Number]

MFCD21363632
[MOL File]

1228664-49-0.mol
[Molecular Weight]

446.91
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
[form ]

A solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302+H312+H332-H315-H319
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501
Hazard InformationBack Directory
[Description]

Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).
[Uses]

Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.
[storage]

Store at -20°C
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