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ChemicalBook--->CAS DataBase List--->1227401-27-5

1227401-27-5

1227401-27-5 Structure

1227401-27-5 Structure
IdentificationBack Directory
[Name]

GN25
[CAS]

1227401-27-5
[Synonyms]

GN25
DIIRLGMLDOPLPV-UHFFFAOYSA-N
[Molecular Formula]

C15H14O6S
[MOL File]

1227401-27-5.mol
[Molecular Weight]

322.33
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

≤0.25mg/ml in ethanol;5mg/ml in DMSO;10mg/ml in dimethyl formamide
[form ]

crystalline solid
Hazard InformationBack Directory
[Description]

The tumor suppressor gene, p53, is often mutated or suppressed in human cancers. Oncogenic K-Ras has been shown to inhibit p53 function by inducing Snail to bind and eliminate p53 through exocytosis. GN25 is a 2-thio-dimethoxy naphthoquinone analog that blocks Snail binding to p53 and induces p53 expression in cancer cells in a K-Ras dependent manner. At 10 μM, GN25 significantly reduces cell proliferation in K-Ras mutated A549 and HCT116 cell lines but not in wild type MKN-45 cells. In a xenograft mouse model, 10 mg/kg GN25 yields antitumoral effects by notably reducing tumor size and progression.
[References]

[1]. lee sh, shen gn, jung ys, et al. antitumor effect of novel small chemical inhibitors of snail-p53 binding in k-ras-mutated cancer cells. oncogene. 2010 aug 12;29(32):4576-87.
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