| Identification | Back Directory | [Name]
SGD 1882 | [CAS]
1222490-34-7 | [Synonyms]
SGD 1882
PBD dimer
SGD1882,SGD 1882
5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 2-(4-aminophenyl)-8-[3-[[(11aS)-5,11a-dihydro-7-methoxy-2-(4-methoxyphenyl)-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl]oxy]propoxy]-1,11a-dihydro-7-methoxy-, (11aS)- | [Molecular Formula]
C42H39N5O7 | [MDL Number]
MFCD27952508 | [MOL File]
1222490-34-7.mol | [Molecular Weight]
725.79 |
| Chemical Properties | Back Directory | [Boiling point ]
977.7±65.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
5.07±0.10(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
OMRPLUKQNWNZAV-CONSDPRKSA-N | [SMILES]
N1C2=CC(OCCCOC3C=C4N=C[C@]5([H])CC(C6=CC=C(OC)C=C6)=CN5C(=O)C4=CC=3OC)=C(OC)C=C2C(=O)N2C=C(C3=CC=C(N)C=C3)C[C@@]2([H])C=1 |
| Hazard Information | Back Directory | [Uses]
SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs. | [References]
[1] Eunhee G. Kim, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted Cancer Therapeutics. Biomol Ther (Seoul). 2015 Nov; 23(6): 493-509.
[2] Dowdy Jackson, et al. Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates. Pharm Res. 2015; 32(11): 3458-3469. |
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