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ChemicalBook--->CAS DataBase List--->121842-79-3

121842-79-3

121842-79-3 Structure

121842-79-3 Structure
IdentificationBack Directory
[Name]

TETRANOR-12(S)-HETE
[CAS]

121842-79-3
[Synonyms]

TETRANOR-12(S)-HETE
KBOVKDIBOBQLRS-ONCCEEIJSA-N
4,6,10-Hexadecatrienoic acid, 8-hydroxy-, [S-(E,Z,Z)]- (9CI)
[Molecular Formula]

C16H26O3
[MDL Number]

MFCD08457913
[MOL File]

121842-79-3.mol
[Molecular Weight]

266.38
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

0.1 M Na2CO3: 2 mg/ml; DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): .5 mg/ml
Safety DataBack Directory
[Symbol(GHS) ]


GHS02,GHS07
[Signal word ]

Danger
[Hazard statements ]

H225-H319
[Precautionary statements ]

P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
Hazard InformationBack Directory
[Description]

12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetranor-12(S)-HETE. Some data indicate it may play a role in controlling the inflammatory response in injured corneas. In some diseases (e.g., Zellweger’s Syndrome) peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may be responsible for symptoms of the disease. The tetranor derivative of 12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound.
[Uses]

Tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE (HY-124404A) in numerous tissues. 12(S)‐HETE to tetranor‐12(S)‐HETE conversion could be a marker for psoriasis[1].
[Definition]

ChEBI: Tetranor 12-HETE is a hydroxy fatty acid.
[References]

[1] Setkowicz M, et al. Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid. Br J Dermatol. 2015 Feb;172(2):337-44. DOI:10.1111/bjd.13225
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