| Identification | Back Directory | [Name]
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate | [CAS]
1216744-19-2 | [Synonyms]
SR6452
SK4112
GSK 4112
GSK4112,SR6452
SR6452; SR-6452; SR 6452
tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate
tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C18H21ClN2O4S | [MDL Number]
MFCD12912412 | [MOL File]
1216744-19-2.mol | [Molecular Weight]
396.89 |
| Chemical Properties | Back Directory | [Melting point ]
95 - 96°C | [Boiling point ]
486.7±45.0 °C(Predicted) | [density ]
1.296±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly, Heated) | [form ]
powder | [pka]
3.87±0.50(Predicted) | [color ]
off-white to tan |
| Hazard Information | Back Directory | [Uses]
GSK 4112 is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis. | [Biochem/physiol Actions]
GSK4112 is a rev-erbα, (orphan nuclear receptor NR1D1) agonist, the first agent able to reset the circadian clock in a phase-dependent manner. Rev-erbα impacts the precision of the circadian clock by repressing target gene activities with the help of a nuclear receptor co-repressor complex (NCoR) and HDAC3. GSK4112 competes with heme (rev-erb′s natural ligand) and enhances co-repressor complex recruitment and thus, repression of transcription. suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases, especially disorders of adipogenesis regulated by rev-erba. | [storage]
Store at +4°C |
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