| Identification | Back Directory | [Name]
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid | [CAS]
1215197-37-7 | [Synonyms]
PF 04991532
PF-04991532
PF 04991532,PF04991532
PF-04991532 >=98% (HPLC)
(S)-6-(3-Cyclopentyl-2-(4-(trifluoroMethyl)-1H-iMidazol- 1-yl)propanaMido)nicotinic Acid
6-[[(2S)-3-Cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]-3-pyridinecarboxylic acid
3-Pyridinecarboxylic acid, 6-[[(2S)-3-cyclopentyl-1-oxo-2-[4-(trifluoromethyl)-1H-imidazol-1-yl]propyl]amino]- | [Molecular Formula]
C18H19F3N4O3 | [MDL Number]
MFCD27938256 | [MOL File]
1215197-37-7.mol | [Molecular Weight]
396.36 |
| Chemical Properties | Back Directory | [Boiling point ]
646.5±55.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [pka]
3.55±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
PF 04991532 is a useful research chemical used as a hepatoselective glucokinase activator for treating type 2 diabetes mellitus. | [Biological Activity]
PF-04991532 is a potent and hepatoselective glucokinase activator th at reduces mean daily glucose (MDG)fasting plasma glucose (FPG) and glucose excursion in humans. | [in vivo]
A single dose of PF-04991532 increases the glucose infusion rate in order to maintain hyperglycemia. Despite the elevations in plasma triglycerides, surprisingly, hepatic triglycerides in rats dosed with 19 days of PF-04991532 are identical to vehicle treated GK rats. In an additional cohort treated for 28 days, identical hepatic lipid concentrations are observed between vehicle and rats dosed with PF-04991532 (Vehicle: 9.89±0.31; PF-04991532 100 mg/kg: 9.91±0.31). In rats treated with PF-04991532, there is increased expression of lipogenic gene expression such as acetyl-CoA carboxylase (ACC), ATP citrate lyase (ACLY), and fatty acid synthase (FAS)[1]. | [storage]
Store at -20°C |
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Energy Chemical
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http://www.energy-chemical.com |
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InvivoChem
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Merck KGaA
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