| Identification | Back Directory | [Name]
KAG-308 | [CAS]
1215192-68-9 | [Synonyms]
KAG-308
KAG 308,KAG308
2H-Cyclopenta[b]furan-5-ol, 3,3-difluorohexahydro-4-[(1E,3R,4R)-3-hydroxy-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(2H-tetrazol-5-yl)butylidene]-, (2Z,3aR,4R,5R,6aS)- | [Molecular Formula]
C24H30F2N4O3 | [MDL Number]
MFCD32174306 | [MOL File]
1215192-68-9.mol | [Molecular Weight]
460.52 |
| Chemical Properties | Back Directory | [Boiling point ]
615.6±65.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
5.00±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a Ki and an EC50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor[1]. | [storage]
Store at -20°C | [References]
[1] Watanabe Y, et al. KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration. Eur J Pharmacol. 2015 May 5;754:179-89. DOI:10.1016/j.ejphar.2015.02.021 |
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