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ChemicalBook--->CAS DataBase List--->1215085-93-0

1215085-93-0

1215085-93-0 Structure

1215085-93-0 Structure
IdentificationBack Directory
[Name]

GLPG0492 (R enantiomer)
[CAS]

1215085-93-0
[Synonyms]

GLPG0492 (R enantiomer)
GLPG-0492 R enantiomer (GLPG0492 R enantiomer)
Benzonitrile, 4-[(4R)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-
[Molecular Formula]

C19H14F3N3O3
[MOL File]

1215085-93-0.mol
[Molecular Weight]

389.33
Chemical PropertiesBack Directory
[Boiling point ]

544.0±60.0 °C(Predicted)
[density ]

1.50±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

13.50±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, which is a novel selective androgen receptor modulator.
[storage]

Store at -20°C
[References]

[1] Nique F, et al. Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator. J Med Chem. 2012 Oct 11;55(19):8236-47. DOI:10.1021/jm300281x
[2] Cozzoli A, et al. GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy. Pharmacol Res. 2013 Jun;72:9-24. DOI:10.1016/j.phrs.2013.03.003
[3] Blanqué R, et al. Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization. BMC Musculoskelet Disord. 2014 Sep 3;15:291. DOI:10.1186/1471-2474-15-291
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