| Identification | Back Directory | [Name]
BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]- | [CAS]
1208123-85-6 | [Synonyms]
CaMKII-IN-1
CaMKII inhibitor 1
N-[6-benzyl-2-(2-phenylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]-3-chloro-2-methylbenzenesulfonamide
N-{6-Benzyl-2-[(2-phenylethyl)amino]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl}-3-chloro-2-methylbenzenesulfonamide
3-chloro-2-methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)amino]-6-(phenylmethyl)pyrido[4,3-d]pyrimidin-4-yl]benzenesulfonamide
BenzenesulfonaMide, 3-chloro-2-Methyl-N-[5,6,7,8-tetrahydro-2-[(2-phenylethyl)aMino]-6-(phenylMethyl)pyrido[4,3-d]pyriMidin-4-yl]- | [Molecular Formula]
C29H30ClN5O2S | [MDL Number]
MFCD25977086 | [MOL File]
1208123-85-6.mol | [Molecular Weight]
548.1 |
| Chemical Properties | Back Directory | [Melting point ]
208-210 °C (decomp) | [Boiling point ]
728.2±70.0 °C(Predicted) | [density ]
1.349±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 54 mg/mL (98.52 mM) | [form ]
Solid | [pka]
3.94±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.
IC50 value: 63 nM
Target: CaMKII | [storage]
Store at -20°C | [References]
[1] Asano S, et al. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6696-8. DOI:10.1016/j.bmcl.2010.09.005 |
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| Company Name: |
BOC Sciences
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16314854226 |
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www.bocsci.com |
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Musechem
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