| Identification | Back Directory | [Name]
Sulopenem | [CAS]
120788-07-0 | [Synonyms]
CP-70429
Sulopenem
CP-65207-S
Sulopenem USP/EP/BP
(S)-3-[[(5R)-2-Carboxy-6β-[(R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]tetrahydrothiophene 1-oxide
(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-, (5R,6S)- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C12H15NO5S3 | [MDL Number]
MFCD00865089 | [MOL File]
120788-07-0.mol | [Molecular Weight]
349.45 |
| Chemical Properties | Back Directory | [Boiling point ]
693.1±55.0 °C(Predicted) | [density ]
1.74±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
3.88±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
Sulopenem is a parenteral penem that demonstrates high activity against Gram-positive, Gram-negative, and anaerobic bacteria. Since it is stable in relation to renal dehydropeptidase I, it does not require concomitant administration of an inhibitor of this enzyme. | [Uses]
Antibacterial. | [Mechanism of action]
Sulopenem is one of the penems and, as such, interacts with penicillin-binding proteins (PBPs). From in vitro studies, sulopenem has shown a high affinity for PBP1a, 1b, 2, and 3 in E. coli. | [Pharmacokinetics]
When 1 g of CP-65,207 [containing 46.3% of S-isomer (sulopenem)
and 53.7% of R-isomer] was administered by 10-minute intravenous
infusions, the peak concentration of sulopenem in serum was 36.0 mg/
ml, its half-life was 52.8 minutes, and the area under the serum
concentration-versus-time curve (AUC) from 0 to 8 hours was
21.0 mg/ml per hour. |
|
| Company Name: |
Twochem Co.Ltd
|
| Tel: |
021-021-58111628 15800915896 |
| Website: |
www.twochem.com |
| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
|