| Identification | Back Directory | [Name]
CBZ-AEP | [CAS]
1205751-19-4 | [Synonyms]
CBZ-AEP
CBZ-NH-PEG1-acid
CBZ-NH-PEG1-propionic acid
3-[2-(Cbz-amino)ethoxy]propanoic acid | [Molecular Formula]
C13H17NO5 | [MDL Number]
MFCD14582436 | [MOL File]
1205751-19-4.mol | [Molecular Weight]
267.28 |
| Chemical Properties | Back Directory | [Boiling point ]
476.2±40.0 °C(Predicted) | [density ]
1.225±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.29±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
3-[2-(Cbz-amino)ethoxy]propanoic acid is a PEG linker containing an carboxylic acid (CO2H) group and a benzyl (Cbz) protecting group. The terminal carboxylic acid is reactive with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis to form a free amine. | [Uses]
Cbz-NH-PEG1-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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