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ChemicalBook--->CAS DataBase List--->1197824-15-9

1197824-15-9

1197824-15-9 Structure

1197824-15-9 Structure
IdentificationBack Directory
[Name]

Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-
[CAS]

1197824-15-9
[Synonyms]

EN4 MYC inhibitor
Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-
[Molecular Formula]

C25H24N2O4
[MDL Number]

MFCD13582116
[MOL File]

1197824-15-9.mol
[Molecular Weight]

416.47
Chemical PropertiesBack Directory
[Boiling point ]

564.1±50.0 °C(Predicted)
[density ]

1.202±0.06 g/cm3(Predicted)
[storage temp. ]

4°C, protect from light
[solubility ]

DMSO : 250 mg/mL (600.28 mM; Need ultrasonic)
[form ]

Solid
[pka]

12.82±0.70(Predicted)
[color ]

White to light yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319-H302-H315-H335
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362
Spectrum DetailBack Directory
[Spectrum Detail]

Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-(1197824-15-9)1HNMR
Hazard InformationBack Directory
[Biological Activity]

EN4 is a cell penetrantpotent and selective covalent c-MYC inhibitor th at targets cysteine 171 located within a predicted intrinsically disordered region of MYC. EN4 inhibits MYC transcriptional activitydownregulates multiple MYC transcriptional targetsreduces MYC and MAX thermal stabilityand impairs tumorigenesis.
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