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ChemicalBook--->CAS DataBase List--->1197196-63-6

1197196-63-6

1197196-63-6 Structure

1197196-63-6 Structure
IdentificationBack Directory
[Name]

MS0124
[CAS]

1197196-63-6
[Synonyms]

MS0124
[Molecular Formula]

C20H29N5O3
[MOL File]

1197196-63-6.mol
[Molecular Weight]

387.48
Hazard InformationBack Directory
[Description]

MS0124 is a Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. MS0124 was 34-fold more selective for GLP (IC50 =_x000D_ 13 ± 4 nM) over G9a (IC50 = 440 ± 63 nM). G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone substrates
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