| Identification | Back Directory | [Name]
(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE | [CAS]
1192810-88-0 | [Synonyms]
(1S,2R,4S)-N-(ISOQUINOLIN-3-YL)-4H-4-AZASPIRO[BICYCLO[2.2.2]OCTANE-2,5-OXAZOL]-2-AMINE | [Molecular Formula]
C18H20N4O | [MDL Number]
MFCD30828959 | [MOL File]
1192810-88-0.mol | [Molecular Weight]
308.39 |
| Hazard Information | Back Directory | [Description]
BMS-902483 is a potent α7 partial agonist, which improved cognition in preclinical rodent models. BMS-902483 showed FLIR α7 EC50=9.3nM; α7 Electrophysiology, rat; Area EC50 = 140 nM; Peak, Area (Ymax %) = 40, 54. 5-HT3A IC50 = 480 nm. Preclinical and early clinical data suggest that α7 nicotinic acetylcholine receptor (nAChR) agonists have potential for the treatment of cognitive and negative symptoms in schizophrenia patients |
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| Company Name: |
AstaTech, Inc
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| Tel: |
(215) 785 3197 |
| Website: |
www.astatechinc.com |
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