成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->1191252-49-9

1191252-49-9

1191252-49-9 Structure

1191252-49-9 Structure
IdentificationBack Directory
[Name]

iOWH-032
[CAS]

1191252-49-9
[Synonyms]

iOWH-032
3-(3,5-DibroMo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxaMide
3-(3,5-Dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide
1,2,4-Oxadiazole-5-carboxamide, 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-
3-(3,5-Dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide IOWH032
[Molecular Formula]

C22H15Br2N3O4
[MDL Number]

MFCD25977119
[MOL File]

1191252-49-9.mol
[Molecular Weight]

545.18
Chemical PropertiesBack Directory
[density ]

1.670±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

≥21.85 mg/mL in DMSO; insoluble in H2O; ≥3.13 mg/mL in EtOH with gentle warming
[form ]

solid
[pka]

3.34±0.46(Predicted)
[color ]

White to off-white
Questions And AnswerBack Directory
[Description]

IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.
[In vitro]

IOWH032 shows inhibitory activity against CFTR in T84-CFTR cell based assays with IC50 of 6.87 μM.
[In vivo]

In a mouse closed-loop model, IOWH032 causes a statistical significant inhibition against cholera toxin (CTX) induced secretion. IOWH032 (5 mg/kg) reduces the fecal output index by ~70% in a cecetomized rat model.
Hazard InformationBack Directory
[Uses]

IOWH032 is a synthetic?cystic fibrosis transmembrane conductance regulator (CFTR) ?inhibitor.
[Biological Activity]

iowh-032 is a potent and synthetic extracellular cystic fibrosis transmembrane conductance regulator (cftr) inhibitor with ic50 value of 1.01 μm in t84 and cho-cftr cell based assays [1]. the cftr chloride channel is the most attractive because it is the primary driver of secretion in cases of diarrhea caused by enterotoxigenic bacteria. cftr plays an important role in transepithelial fluid homeostasis through controlling the flow of chloride ions and thus the movement of water in and out of cells [1].
[target]

cftr
[IC 50]

1.01 μm
[References]

1. doyle k, et al. inhibitors of the cftr chloride ion channel as potential treatment for acute secretory diarrhea: development of 5-membered heterocycles suitable for pre-clinical evaluation.1. de hostos el, choy rk, nguyen t. developing novel antisecretory drugs to treat infectious diarrhea. future med chem. 2011;3(10):1317-25. 2. cui g, khazanov n, stauffer b, infield dt, imhoff br, senderowitz h, et al. potentiators exert distinct effects on human, murine, and xenopus cftr. am j physiol lung cell mol physiol. 2016:ajplung 00056 2016.
Spectrum DetailBack Directory
[Spectrum Detail]

iOWH-032(1191252-49-9)1HNMR
1191252-49-9 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Website: www.hubeijusheng.com
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: Hefei Hirisun Pharmatech Co., Ltd
Tel: +8615056975894 , +8615056975894
Website: www.hirisunpharm.com
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Website: www.boylechem.com
Company Name: Dalian Meilun Biotech Co., Ltd.  
Tel: 0411-62910999 13889544652
Website: http://www.meilune.com/
Company Name: Haoyuan Chemexpress Co., Ltd.  
Tel: 021-58950125
Website: http://www.chemexpress.com.cn
Company Name: Shanghai Aladdin Bio-Chem Technology Co.,LTD  
Tel: 400-400-6206333 18521732826
Website: www.aladdin-e.com/
Company Name: MedChemexpress LLC  
Tel: 021-58955995
Website: www.medchemexpress.cn
Company Name: EnliPharma Technology Co., Ltd  
Tel: 0551-66399836 18955197623
Website: http://www.enlipharma.com
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  
Tel: 020-39119399 18927568969
Website: http://www.isunpharm.com
Company Name: AdooQ BioScience, LLC   
Tel: +1 (866) 930-6790
Website: www.adooq.com
Tags:1191252-49-9 Related Product Information
129830-38-2 873054-44-5 936727-05-8 943319-70-8 307510-92-5 915019-65-7