| Identification | Back Directory | [Name]
AMG90903 | [CAS]
118215-82-0 | [Synonyms]
AMG90903
AMG 9090
N-[2,2,2-TRICHLORO-1-(4-CHLOROPHENYL)SULFANYLETHYL]BENZAMIDE
Benzamide, N-[2,2,2-trichloro-1-[(4-chlorophenyl)thio]ethyl]- | [Molecular Formula]
C15H11Cl4NOS | [MDL Number]
MFCD00402373 | [MOL File]
118215-82-0.mol | [Molecular Weight]
395.13 |
| Hazard Information | Back Directory | [Description]
AMG9090 is a transient receptor potential ankyrin 1 (TRPA1) antagonist. | [Uses]
AMG 9090 is characterized as a compound that acts as a partial agonist of rat TRPA1 channels, demonstrating pharmacological activity in pain and inflammation models. TRPA1 is pivotal in sensing reactive compounds, triggering pain responses in humans and rodents. AMG 9090, along with other trichloro(sulfanyl)ethyl benzamides (TCEB compounds), shows differential effects on human and rat TRPA1 channels: it acts as a potent antagonist of human TRPA1 activated by AITC and noxious cold, whereas it behaves as a partial agonist at rat TRPA1. This suggests AMG 9090's potential as a therapeutic agent targeting TRPA1-mediated pain and inflammation, with additional inhibitory activity against TRPM8 noted[1]. | [References]
[1] Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists |
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Alomone Labs
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1-972 2-587-2202 13121892008 |
| Website: |
www.alomone.com |
| Company Name: |
Specs
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+31 15 251 8111 |
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www.specs.net |
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