| Identification | Back Directory | [Name]
EMD638683 | [CAS]
1181770-72-8 | [Synonyms]
EMD638683
]-2-ethyL
N'-[2-(3,5-DifL
)-2-hydroxyacetyL
-4-hydroxy-3-methyL
EMD 638683;EMD-638683
N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide
Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide
3,5-Difluoro-alpha-hydroxybenzeneacetic acid 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide | [Molecular Formula]
C18H18F2N2O4 | [MDL Number]
MFCD25541743 | [MOL File]
1181770-72-8.mol | [Molecular Weight]
364.34 |
| Chemical Properties | Back Directory | [Boiling point ]
657.6±55.0 °C(Predicted) | [density ]
1.363±0.06 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
insoluble in H2O; ≥18.2 mg/mL in DMSO; ≥45.8 mg/mL in EtOH with gentle warming | [form ]
solid | [pka]
8.68±0.25(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Biological Activity]
EMD638683 is an orally active and highly selective serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 = 3 μM against HeLa cellular NDRG1 phosphorylation) th at significantly decreased blood pressure in fructose-treated mice but not in control saline-treated or in SGK1-knockout animals (4460 ppm in chow~600 mg/kg/day). EMD638683 promotes radiation-induced suicidal death of CaCo-2 colon tumor cells in vitro (50 μM) and decreases the number of colonic tumors following chemical carcinogenesis in vivo (4460 ppm in chow). | [target]
SGK1 |
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