| Identification | Back Directory | [Name]
4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid | [CAS]
1181226-02-7 | [Synonyms]
ZL006
ZL 006;ZL006
4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
Benzoic acid, 4-[[(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-2-hydroxy- | [Molecular Formula]
C14H11Cl2NO4 | [MDL Number]
MFCD20527326 | [MOL File]
1181226-02-7.mol | [Molecular Weight]
328.15 |
| Chemical Properties | Back Directory | [Boiling point ]
530.4±50.0 °C(Predicted) | [density ]
1.617±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥5mg/mL (warmed to 60° C) | [form ]
powder | [pka]
3.40±0.10(Predicted) | [color ]
white to tan |
| Hazard Information | Back Directory | [Biochem/physiol Actions]
ZL006 inhibits the ischemia-induced interaction of nNOS with postsynaptic density protein-95 (PSD-95), preventing glutamate-induced excitotoxicity and cerebral ischemic damage. It does not inhibit nNOS itself. ZL006 is brain penetrant, and has been tested in both rat and mouse models of stroke. |
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