| Identification | Back Directory | [Name]
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine | [CAS]
1156491-10-9 | [Synonyms]
Ticagrelor USP RC A
Ticagrelor side chain 2 hydrochloride
(1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo
2-(3,4-Difluoro-phenyl)-cyclopropylamine
(1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl
trans-(1R,2S)-2-(3,4-difluorphenyl)cyclopropylaMine
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
(1R,2S)-2-(3,4-Difluorophenyl)-cyclopropan-1-aMine HCL
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine HCl
trans-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride
1R trans)-2-(3,4-difluorophenyl)cyclopropane amine in stock
(1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride,
(1R,2S)-REL-2-(3,4-difluorophenyl)cyclopropane amine chloride
(1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride
trans-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochl...
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1)
trans-(1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride
(1R, 2S) - REL-2- (3,4-difluorophenyl) cyclopropylamine hydrochloride
(1R,2S)-rel-2-(3,4-Difluorophenyl)-cyclopropanamine hydrochloride (1:1)
CYCLOPROPANAMINE, 2-(3,4-DIFLUOROPHENYL)-, HYDROCHLORIDE (1:1), (1R,2S)-REL-
(1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochlorideQ: What is
(1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the CAS Number of
(1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the storage condition of
(1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride | [EINECS(EC#)]
829-852-9 | [Molecular Formula]
C9H10ClF2N | [MDL Number]
MFCD16875501 | [MOL File]
1156491-10-9.mol | [Molecular Weight]
205.632 |
| Chemical Properties | Back Directory | [Melting point ]
>172°C (dec.) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White | [InChI]
InChI=1/C9H9F2N.ClH/c10-7-2-1-5(3-8(7)11)6-4-9(6)12;/h1-3,6,9H,4,12H2;1H/t6-,9+;/s3 | [InChIKey]
IMYLOCHFFLYHPS-RHUSADAZNA-N | [SMILES]
N[C@@H]1C[C@H]1C1C=CC(F)=C(F)C=1.Cl |&1:1,3,r| |
| Hazard Information | Back Directory | [Uses]
(1S,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine is an intermediate used to prepare ticagrelor (T437700). | [Synthesis Reference(s)]
Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts. EU Patent EP2644590A1
| [Synthesis]
 1,2-Difluorobenzene is reacted with 3-chloropropionyl chloride to
produce 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one, which is by
addition of N,N-dimethylformamide,
phloroglucinol and sodium iodide in the next step converted to
1-(3',4'-difluorophenyl)-3-nitro-propan-1-one. The keto group of the
latter intermediate is in the subsequent step stereochemically reduced
to hydroxyl group by the use of chiral oxazaborolidine together with
borane dimethyl sulfide or borane-N,N-diethyl aniline complex in the presence of tetrahydrofurane. The obtained (1R)-1-(3',4'-difluorophenyl)-3-nitro-propan-1-ol
is then added to a mixture of triphenylphosphine and
diethylazodicarboxylate in benzene to yield (1S,2R)-2-(3',4'-difluorophenyl)-1-nitrocyclopropane, which is in the last step converted to 2-(3,4-difluorophenyl)cyclopropane amine by reduction of the nitro group by catalytic hydrogenation with palladium catalyst and zink dust. |
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