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ChemicalBook--->CAS DataBase List--->115116-37-5

115116-37-5

115116-37-5 Structure

115116-37-5 Structure
IdentificationBack Directory
[Name]

L-858051
[CAS]

115116-37-5
[Synonyms]

L-858051
L-858,051 (hydrochloride)
L858,051 (hydrochloride),L 858,051 (hydrochloride)
7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL
FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE
8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL
[Molecular Formula]

C29H50Cl2N2O7
[MDL Number]

MFCD00077349
[MOL File]

115116-37-5.mol
[Molecular Weight]

609.62
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 20 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
[form ]

A crystalline solid
[color ]

white
[Water Solubility ]

water: 12mg/mL
methanol: soluble
Hazard InformationBack Directory
[Description]

L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase.1 L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes.2 L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.3,4,5
[storage]

Store at -20°C
[References]

1. Laurenza, A., Khandelwal, Y., De Souza, N.J., et al. Stimulation of adenylate cyclase by water-soluble analogues of forskolin Mol. Pharmacol. 32(1),133-139(1987).
2. Joost, H.G., Habberfield, A.D., Simpson, I.A., et al. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action Mol. Pharmacol. 33(4),449-453(1988).
3. Funaki, C., Hodges, R.R., and Dartt, D.A. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland Am. J. Physiol. Cell Physiol. 293(5),C1551-C1560(2007).
4. Luo, S.-F., Chiu, C.-T., Tsao, H.-L., et al. Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells Cell. Signal. 9(2),159-167(1997).
5. Haj Slimane, Z., Bedioune, I., Lechêne, P., et al. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes Cardiovasc. Res. 102(1),97-106(2014).
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