| Identification | Back Directory | [Name]
Z-D-ARG-GLY-ARG-PNA 2 HCL | [CAS]
113711-77-6 | [Synonyms]
Z-RGR-PNA
CHROMOGENIX
Chromogenix S-2238
Chromogenic Assays
Z-D-Arg-Gly-Arg-pNA
S-2765(FXa substrate)
Cbz-D-Arg-Gly-Arg-pNA
H-D-Phe-Pip-Arg-pNA·2HCl
Z-D-ARG-GLY-ARG-PNA 2 HCL
Chromogenic Substrate for Thrombin
Z-D-Arg-Gly-Arg-pNA (hydrochloride)
S2765 ;S 2765;Z-D-ARG-GLY-ARG-PNA.2HCL
benzyl N-[(2R)-5-(diaminomethylideneamino)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopentan-2-yl]carbamate | [Molecular Formula]
C28H41Cl2N11O7 | [MDL Number]
MFCD03093407 | [MOL File]
113711-77-6.mol | [Molecular Weight]
714.6 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 14 mg/ml; DMSO: 14 mg/ml; Ethanol: partially soluble; PBS (pH 7.2): 0.5 mg/ml | [form ]
A solid | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
Z-D-Arg-Gly-Arg-pNA is a colorimetric substrate for Factor Xa.1,2 Factor Xa preferentially binds to and cleaves the Arg-Gly-Arg (RGR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of Factor Xa activity. | [Uses]
Z-D-Arg-Gly-Arg-pNA Dihydrochloride is a reagent used in the preparation and testing of tripeptides and intermediates (arginine-containing) as reagent for the determination of serine protease. | [References]
1. Gustavsson, S.I., and Arielly, S. New Peptide Derivatives ,(1989).
2. Joo, H.-S., Park, G.-C., Kim, K.-M., et al. Novel alkaline protease from the polychaeta, Periserrula leucophryna: Purification and characterization Proc. Biochem. 36(8-9),893-900(2001). |
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