| Identification | Back Directory | [Name]
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone | [CAS]
1125812-58-9 | [Synonyms]
3'-Chloro-5'-trifluoroMethyl-2,2,2-trifluoroacetophenone
2,2,2-trifluoro-3'-chloro-5'-trifluoromethylacetophenone
3'-Chloro-5'-trifluoromethoxy-2,2,2-trifluoroacetophenone
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone
1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one
Ethanone, 1-[3-chloro-5-(trifluoromethyl)phenyl]-2,2,2-trifluoro-
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone ISO 9001：2015 REACH
1-(3-chloro-5-(trifluoromethyl)phenyl)-2,2,2-trifluoroethan-1-one
(Afoxolaner intermediate） | [Molecular Formula]
C9H3ClF6O | [MDL Number]
MFCD19440960 | [MOL File]
1125812-58-9.mol | [Molecular Weight]
276.56 |
| Hazard Information | Back Directory | [Uses]
1-[3-Chloro-5-trifluoromethylphenyl]-2,2,2-trifluoroethanone can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | [Synthesis]
Cool the solution containing compound III (74.4g, 0.255mol containing compound III) to -100, and add 120g of sulfuric acid with a mass fraction of 92.5% to the above system while keeping the temperature below 0. After acidification, continue to react and keep for 1.5h, and then add 126.7g of 33% sodium nitrite aqueous solution (containing diazotizing reagent sodium nitrite 0.612mol) into the system uniformly within 2h, and keep the temperature at 0 The following reaction is carried out for 2 hours, and the system is heated to room temperature after full reaction, 111.1 g of 50% hypophosphorous acid and 0.67 g of cuprous oxide are added, and the reaction is stirred for 2 hours while keeping temperature. After the reaction is over, stand to separate the layers, and wash the organic layer with a 5% sodium bicarbonate aqueous solution, dry with anhydrous magnesium sulfate, and rectify to obtain a clear and transparent oily liquid 1-[3-chloro-5-(trifluoromethyl) (Yl)phenyl]-2,2,2-trifluoroethanone 66.9, content 99.5%, yield 87.2%. |
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