| Identification | Back Directory | [Name]
3'-Demethylnobiletin | [CAS]
112448-39-2 | [Synonyms]
3'-Hydroxy-5
3'-Demethylnobiletin
2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one
4H-1-Benzopyran-4-one, 2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxy- | [Molecular Formula]
C20H20O8 | [MDL Number]
MFCD21333408 | [MOL File]
112448-39-2.mol | [Molecular Weight]
388.37 |
| Chemical Properties | Back Directory | [Melting point ]
170-171 °C | [Boiling point ]
613.8±55.0 °C(Predicted) | [density ]
1.304±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.95±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits[1]. Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling[2]. | [Definition]
ChEBI: 3'-Hydroxy-4',5,6,7,8-pentamethoxyflavone is a member of flavonoids and an ether. | [References]
[1] Murakami A, et al. In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits. Biosci Biotechnol Biochem. 2001 Jan;65(1):194-7. DOI:10.1271/bbb.65.194
[2] Sp N, et al. Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER+ Breast Cancer Cells. Int J Mol Sci. 2017 Apr 30;18(5). pii: E935. DOI:10.3390/ijms18050935 |
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