| Identification | Back Directory | [Name]
2H-Benzimidazol-2-one, 1-[4-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)butyl]-1,3-dihydro-3-methyl- | [CAS]
1121931-70-1 | [Synonyms]
CM398
2H-Benzimidazol-2-one, 1-[4-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)butyl]-1,3-dihydro-3-methyl- | [Molecular Formula]
C23H29N3O3 | [MOL File]
1121931-70-1.mol | [Molecular Weight]
395.49 |
| Chemical Properties | Back Directory | [Boiling point ]
536.7±50.0 °C(Predicted) | [density ]
1.166±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (632.13 mM; Need ultrasonic) | [form ]
Solid | [pka]
8.09±0.20(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Biological Activity]
CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice[1]. | [References]
[1]. Intagliata S, et al. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. AAPS J. 2020;22(5):94. Published 2020 Jul 20. |
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