| Identification | Back Directory | [Name]
Dehydroevodiaminehydrochloride | [CAS]
111664-82-5 | [Synonyms]
14-methyl-5-oxo-7,8,13,14-tetrahydro-5H-indolo[2,3:3,4]pyrido[2,1-b]q | [Molecular Formula]
C19H16ClN3O | [MOL File]
111664-82-5.mol | [Molecular Weight]
337.803 |
| Chemical Properties | Back Directory | [Melting point ]
198 °C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMF: 2.5 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 2.5 mg/ml | [form ]
A crystalline solid | [color ]
White to yellow |
| Hazard Information | Back Directory | [Biological Activity]
Dehydroevodiamine is the major alkaloid of Evodia rutaecarpa th at exhibit cardiovascular effects such as bradycardiahypotensionand vasorelaxation. Dehydroevodiamine potently inhibits hERG channels. Apparently it is a blocker of IKr (rapid delayed rectifier current) with proarrhythmic effects in vitro and in vivo. Dehydroevodiamine ameliorates the spatial memory impairment in the scopolamine-induced amnestic rats. It reduced neurotoxicity and the production of A?-induced ROS in primary cortical neurons. | [storage]
4°C, protect from light |
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www.bocsci.com |
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