| Identification | Back Directory | [Name]
IAXO-102 | [CAS]
1115270-63-7 | [Synonyms]
IAXO-102
α-D-Glucopyranoside, methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl- | [Molecular Formula]
C35H71NO5 | [MDL Number]
MFCD31813901 | [MOL File]
1115270-63-7.mol | [Molecular Weight]
585.94 |
| Chemical Properties | Back Directory | [Boiling point ]
650.2±55.0 °C(Predicted) | [density ]
0.96±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Ethanol : 50 mg/mL (85.33 mM; Need ultrasonic)|DMSO : 5 mg/mL (8.53 mM; Need ultrasonic) | [form ]
A solid | [pka]
13.00±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
IAXO-102 is a TLR4 antagonist targeting the MD-2 and CD14 co-receptors,which inhibits MAPK and p65 NF-κB phosphorylation and downregulates the expression of TLR4-dependent pro-inflammatory proteins. It inhibits the development of experimental abdominal aortic aneurysm (AAA). | [in vitro]
IAXO-102 (1-10 μM, for 2 hours) inhibits MAPK and p65 NF-κB phosphorylation in human umbilical vein endothelial (HUVEC) cells.
IAXO-102 (10 μM, for 17 hours) suppresses LPS induced proinflammatory proteins MCP-1 and IL-8 production in HUVEC. Western Blot Analysis | Cell Line: | Human umbilical vein endothelial (HUVEC) cells | | Concentration: | 1-10 μM | | Incubation Time: | Pretreatment for 1 hour and then exposed to LPS (100 ng/mL) for additional 1 hour | | Result: | Significantly inhibited LPS- stimulated MAPK/p65nF-ΚB phosphorylation. | | [in vivo]
IAXO-102 (3 mg/kg/day, sc for 28 days) significantly retards Angiotensin II induced increase in aortic diameter in mice. | Animal Model: < /td> | Six-monthold ApoE ?/? /C57Bl6 | | Dosage: | 3 mg/kg/day | | Administration: | SC for 28 days | | Result: | Significantly retarded Angiotensin II -induced increase in aortic diameter. | | [target]
| Target | Value | TLR4
() | MAPK
() | NF-κB
() |
|
|
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
ChemeGen 中國
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
|