| Identification | Back Directory | [Name]
Erythromycin A Oxime | [CAS]
111321-02-9 | [Synonyms]
Erythromycin A Oxime
Erythromycin Impurity J
(9E)-ErythroMycin A OxiMe | [Molecular Formula]
C37H68N2O13 | [MDL Number]
MFCD08062410 | [MOL File]
111321-02-9.mol | [Molecular Weight]
748.941 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
156-166 °C | [Boiling point ]
841.0±65.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
11.96±0.70(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
(9E)-Erythromycin A Oxime is a metabolite of Roxithromycin (R700850) in humans. It has anti-Helicobacter pylori activity | [Uses]
Erythromycin A 9-oxime is a semi-synthetic analogue of erythromycin prepared as means of overcoming acid lability and improving oral absorption of erythromycin A while retaining comparable antibacterial and potency. Although not developed as a commercial product, erythromycin oxime was pivotal in the development of the ring expanded aza-erythromycins (e.g. azithromycin) and the oxime ethers (e.g. roxithromycin). | [Uses]
Erythromycin A 9-oxime is a semi-synthetic analogue of erythromycin prepared as means of overcoming acid lability and improving oral absorption of erythromycin A while retaining comparable antibacterial potency. Although not developed as a commercial product, erythromycin oxime was pivotal in the development of the ring expanded aza-erythromycins (e.g. azithromycin) and the oxime ethers (e.g. roxithromycin). | [Uses]
Intermediate of Azithromycin. Antibacterial agent. | [Description]
(9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin (Item No. 19465).1 |
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