| Identification | Back Directory | [Name]
(SAR9,MET(O2)11)-SUBSTANCE P | [CAS]
110880-55-2 | [Synonyms]
Bhsar-sp
[Sar9, Met(O2)11
[Sar9]SP sulfone
[Sar9]SP sulphone
RPKPQQFFSARLM(O2)
[Sar9,Met(O2)11]SP
9-Sar-substance p sulfone
[Sar9]substance P sulphone
9-Sar-11-Met(o2)-substance p
(SAR9,MET(O2)11)-SUBSTANCE P
Sarcosyl(9)-substance p sulfone
substance P, Sar(9)-Met(O2)(11)-
[SAR9,MET(O2)11]-SUBSTANCE P?, >98%
(SAR9,MET(O2)11)-SUBSTANCE P USP/EP/BP
9-Sarcosyl-11-methionine(o2)-substance p
Bolton hunter-9-sar-11-Met(02)-substance p
Substance P, 9-(N-methylglycine)-, S,S-dioxide
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET(O2)-NH2
H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET(O2)-NH2
Bolton-hunter reagent-substance p. sar(9)-Met(02)(11)
[Sar9,met(o2)11]-substancephighlyspecificneurokininnk1receptor
[SAR9 ,MET(O2 )11 ]-SUBSTANCE P HIGHLY SPECIFIC NEUROKININ NK1 RECEPTOR 97+%
L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Sar-L-Leu-4-(Methylsulfonyl)-L-Abu-NH2
[Sar9,Met(O2)11]-Substance P,Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2?, >98%
(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfonyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide | [Molecular Formula]
C64H100N18O15S | [MDL Number]
MFCD00076787 | [MOL File]
110880-55-2.mol | [Molecular Weight]
1393.66 |
| Chemical Properties | Back Directory | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
H2O : 50 mg/mL (35.88 mM; Need ultrasonic) | [form ]
Lyophilized solid. | [pka]
13.31±0.20(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O2)-NH2 |
| Hazard Information | Back Directory | [Uses]
[Sar9,Met(O2)11]-Substance P is a potent and selective NK1 tachykinin receptor agonist (1). The NK1 tachykinin receptor is a member of the G-protein coupled receptor family and can be found in neurons, brainstem, and vascular endothelial cells (2,3). NK1 tachykinin receptor is a therapeutic target for pancreatic cancer (4). | [Biochem/physiol Actions]
Highly selective NK-1 receptor agonist. | [storage]
Desiccate at -20°C |
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