| Identification | Back Directory | [Name]
N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) | [CAS]
110025-28-0 | [Synonyms]
4OHNDtam
E/Z Endoxifen
Endoxifen (Z/E=3:2)
(E /Z) Endoxifen HCl
4-hydroxy-N-desmethyltamoxifen
N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol
4-[(E)-1-[4-(2-methylaminoethoxy)phenyl]-2-phenyl-but-1-enyl]phenol
4-[(Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol
N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
see H938500 | [Molecular Formula]
C25H27NO2 | [MDL Number]
MFCD09840374 | [MOL File]
110025-28-0.mol | [Molecular Weight]
373.493 |
| Chemical Properties | Back Directory | [Appearance]
Brown Foam | [Melting point ]
63-72°C | [Boiling point ]
519.3±50.0 °C(Predicted) | [density ]
1.099±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform, Dichloromethane, DMSO, Methanol | [form ]
Solid | [pka]
9.38±0.15(Predicted) | [color ]
Light Brown to Light Purple |
| Hazard Information | Back Directory | [Chemical Properties]
Brown Foam | [Uses]
A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line. | [Uses]
A novel active metabolite of the anti-cancer drug Tamoxifen. It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast ca | [in vivo]
Orally administered Endoxifen is rapidly absorbed and systemically available when tested in female rats. The Endoxifen-treated rats show 787% higher exposure (AUC0–∞) and 1,500% higher concentration (Cmax) levels of Endoxifen when compared with Tamoxifen. Oral Endoxifen administration once a day for 28 consecutive days at dosages 2, 4, and 8 mg/kg proves safe and results in progressive inhibition of the growth of the human mammary tumor xenografts in female mice[2]. | [IC 50]
Aromatase; ERα | [storage]
Store at +4°C |
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