| Identification | Back Directory | [Name]
N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE | [CAS]
108825-65-6 | [Synonyms]
Lin28 1632
Lin28-IN-1632
N-METHYL-N-[3-(3-METHYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-YL)PHENYL]ACETAMIDE
Acetamide,N-methyl-N-[3-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]- | [Molecular Formula]
C15H15N5O | [MDL Number]
MFCD01567008 | [MOL File]
108825-65-6.mol | [Molecular Weight]
281.31 |
| Chemical Properties | Back Directory | [Melting point ]
200 °C | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:28.13(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:28.13(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
A crystalline solid | [pka]
0.57±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Lin28 1632 is a small molecule inhibitor of Lin28. | [Biological Activity]
Compound 1632 (C1632) is a RNA-binding protein Lin28 inhibitor th at prevents Lin28-mediated inhibition of let-7 microRNA (miRNA) maturation by blocking Lin28 interaction with let-7 miRNA precursor (IC50 = 8 μM by ELISA using truncated pre-let-7a-2). C1632 specifically upregulates Huh7 cellular let-7a/g/f miRNAbut not RNU44 snoRNA (60 μM for 48h)inhibits the stemness and induces differentiation of mouse embryonic stem cells (mESCs20 μM for 48h)as well as inhibits the proliferation and stem-like properties of human cancer stem cells (CSCs) in 22Rv1 and Huh7 cultures (IC50 20-42 μM). | [storage]
Store at -20°C |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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