| Identification | Back Directory | [Name]
2-Pyridinecarboxylic acid, 5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl- | [CAS]
1079893-79-0 | [Synonyms]
Streptonigrin from Streptomyces flocculus (racemic)
Streptonigrin (racemate)Q: What is
Streptonigrin (racemate) Q: What is the CAS Number of
Streptonigrin (racemate)
2-Pyridinecarboxylic acid, 5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl- | [Molecular Formula]
C25H22N4O8 | [MOL File]
1079893-79-0.mol | [Molecular Weight]
506.46 |
| Chemical Properties | Back Directory | [Melting point ]
289-290 °C(Solv: dichloromethane (75-09-2)) | [Boiling point ]
736.2±60.0 °C(Predicted) | [density ]
1.57±0.1 g/cm3(Predicted) | [pka]
3?+-.0.38(Predicted) |
| Hazard Information | Back Directory | [Uses]
Streptonigrin is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by Streptonigrin are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated. Streptonigrin from Streptomyces flocculus. | [Definition]
ChEBI: Streptonigrin is complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia. It has a role as an antimicrobial agent and an antineoplastic agent. It is a quinolone and a member of pyridines. |
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