| Identification | Back Directory | [Name]
butyryl timolol | [CAS]
106351-79-5 | [Synonyms]
butyryl timolol
O-Butyryltimolol
BUTYRYLTIMOLOL; BUTYRYL TIMOLOL; BUTYRYL-TIMOLOL
Butanoic acid, 1-[[(1,1-dimethylethyl)amino]methyl]-2-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]ethyl ester, (S)- (9CI) | [Molecular Formula]
C17H30N4O4S | [MDL Number]
MFCD32898870 | [MOL File]
106351-79-5.mol | [Molecular Weight]
386.51 |
| Chemical Properties | Back Directory | [Boiling point ]
511.5±50.0 °C(Predicted) | [density ]
1.169±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Liquid | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Butyryltimolol, an effective precursor of Timolol, improves the corneal penetration of Timolol[1]. Butyryltimolol is a β-adrenergic blocker[2]. | [IC 50]
β adrenergic receptor | [References]
[1] Chang SC, et al. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69. DOI:10.1016/s0014-4835(88)80093-9
[2] Potter DE, et al. Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol. Curr Eye Res. 1988 Aug;7(8):755-9. DOI:10.3109/02713688809033206 |
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