| Identification | Back Directory | [Name]
Dehydrocorydaline chloride | [CAS]
10605-03-5 | [Synonyms]
Dehydrocorydaline chloride
13-Methylpalmatine chloride
Dehydrocorydaline chloride, 99.95% | [Molecular Formula]
C22H24ClNO4 | [MDL Number]
MFCD01937870 | [MOL File]
10605-03-5.mol | [Molecular Weight]
401.883 |
| Chemical Properties | Back Directory | [Melting point ]
191-193 °C (decomp) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 20 mg/ml | [form ]
A solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid isolated from the traditional Chinese medicine Corydalis yanhusuo. It regulates Bax, Bcl-2 protein expression; activates caspase-7, caspase-8, and inactivates PARP. Also Dehydrocorydaline chloride can enhance the activation of p38 MAPK and has anti-inflammatory and anti-cancer effects. . | [in vitro]
Dehydrocorydaline significantly inhibits MCF-7 cell proliferation in a dose-dependent manner, which can be reversed by a caspase-8 inhibitor, Z-IETD-FMK. Dehydrocorydaline increases DNA fragments without affecting ΔΨm. Western blotting assay shows that dehydrocorydaline dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression. | [in vivo]
Dehydrocorydaline (3.6, 6 or 10 mg/kg, ip) shows a dose-dependent anticiceptive effect in the acetic acid-induced writhing test and significantly attenuates the formalin-induced pain responses in mice. In the formalin test , dehydrocorydaline decreases the expression of caspase 6 (CASP6), TNF-α, IL-1β and IL-6 proteins in the spinal cord. These findings confirm that Dehydrocorydaline has antinociceptive effects in mice. | [target]
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