| Identification | Back Directory | [Name]
BMS 833923 | [CAS]
1059734-66-5 | [Synonyms]
XL139
XL-139
XL 139
CS-944
BMS 833923
BMS-833923 (XL-139)
BMS 833923 USP/EP/BP
BMS 833923; BMS833923; XL-139; XL139; XL 139
N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide
Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-
N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide BMS-833923
BMS 833923 N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide | [Molecular Formula]
C30H27N5O | [MDL Number]
MFCD25976660 | [MOL File]
1059734-66-5.mol | [Molecular Weight]
473.568 |
| Chemical Properties | Back Directory | [density ]
1.252±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥47.4 mg/mL in DMSO; insoluble in H2O; ≥5.14 mg/mL in EtOH with gentle warming and ultrasonic | [form ]
solid | [pka]
13.42±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models. | [Uses]
BMS 833923 is an antagonist of smoothened, a key hedgehog (Hh) pathway regulator. |
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