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ChemicalBook--->CAS DataBase List--->105925-39-1

105925-39-1

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        105925-39-1 Structure

        105925-39-1 Structure
        IdentificationBack Directory
        [Name]

        Tubulin inhibitor 6
        [CAS]

        105925-39-1
        [Synonyms]

        iHAP1
        Tubulin inhibitor 6
        Methanone, (2-chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)-
        [Molecular Formula]

        C20H14ClNO2S
        [MOL File]

        105925-39-1.mol
        [Molecular Weight]

        367.85
        Chemical PropertiesBack Directory
        [Melting point ]

        155-157 °C
        [Boiling point ]

        549.1±50.0 °C(Predicted)
        [density ]

        1.364±0.06 g/cm3(Predicted)
        [storage temp. ]

        Store at -20°C
        [solubility ]

        DMSO: 62.5 mg/mL (169.91 mM)
        [form ]

        A crystalline solid
        [pka]

        -5.56±0.20(Predicted)
        [color ]

        White to off-white
        Safety DataBack Directory
        [Symbol(GHS) ]


        GHS07
        [Signal word ]

        Warning
        [Hazard statements ]

        H302-H319-H335-H315
        [Precautionary statements ]

        P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501
        Hazard InformationBack Directory
        [Biological Activity]

        Tubulin inhibitor 6 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and efficiently kills malignant cells.
        [in vitro]

        Tubulin inhibitor 6 displays submicromolar antiproliferative activity.

        [target]

        TargetValue
        PP2A
        ()
        [storage]

        Store at -20°C
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