| Identification | Back Directory | [Name]
(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine | [CAS]
1048346-74-2 | [Synonyms]
RO5166017
RO5166017 HCl
(S)-4-((ETHYL(PHENYL)AMINO)METHYL)-4,5-DIHYDROOXAZOL-2-AMINE
(S)-4-[(ethyl-phenyl-amino)-methyl]-4,5-dihydro-oxazol-2-ylamine | [Molecular Formula]
C12H17N3O | [MDL Number]
MFCD22493512 | [MOL File]
1048346-74-2.mol | [Molecular Weight]
219.28 |
| Chemical Properties | Back Directory | [Boiling point ]
355.8±34.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml | [form ]
A crystalline solid | [pka]
8.22±0.70(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
(4S)-4-[(N-Ethylanilino)methyl]-4,5-dihydro-1,3-oxazol-2-amine is an agonist of the trace amine-associated receptor 1 (TAAR1). | [Biological Activity]
Orally activehigh-affinitypotent and selective trace amine-associated receptor 1 (TAAR1) agonist with antipsychotic-like efficacy in vivo.
RO5166017 is an orally activehigh-affinitypotent and selective trace amine-associated receptor 1 (TAAR1) agonist (mouse/rat/human/monkey Ki = 1.9/2.7/31/24 nMcAMP EC50 = 3.3/14/55/97 nM using respective HEK293 transfectants; GIRK EC50 = 8 nM with mTAAR1-expressing Xenopus oocytes; neurons firing frequency IC50 = 1.73/2.99 nM in mouse VTA/DRN slices) with good selectivity over TAAR4 and 123 other proteins. RO5166017 reduces spontaneous hyperlocomotion in Dat-/- mice (0.5 mg/kg ip.)as well as hyperlocomotion induction by cocaine or NMDAR agonist L-687,414 in wild-type (0.01-0.3 mg/kg po.)but not Taar1-knockout mice. | [in vivo]
RO5166017 prevents stress-induced hyperthermia and blocked dopamine-dependent hyperlocomotion in cocaine-treated and dopamine transporter knockout mice as well as hyperactivity induced by an NMDA antagonist[1].
?
RO5166017 (0.01-1 mg/kg, orally) dose-dependently prevents the SIH in NMRI mice. RO5166017 exhibits TAAR1-mediated anxiolytic-like properties at doses 0.1-0.3 mg/kg.[1].
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RO5166017 prevents the cocaine-induced hyperlocomotion. RO5166017 also inhibits stereotypies induced by cocaine in WT mice similar to olanzapine, and this effect is lost in Taar1?/? mice[1].
?
TAAR1 activation by RO5166017 increases glucose-dependent insulin secretion in INS1E cells and human islets and elevated plasma and peptide YY (PYY) and glucagon like peptide 1 (GLP-1) levels in mice[2].?
Subchronic treatment of diet-induced obese (DIO) mice with RO5166017 results in reduced food intake and body weight[2]. |
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