| Identification | Back Directory | [Name]
CGS 15943 | [CAS]
104615-18-1 | [Synonyms]
CGS 15943
CGS-15943A
CGS-15943 solid
CGS-15943 ADENOSINE A1 RECEPTOR
9-CHLORO-2-(2-FURYL)(1,2,4)TRIAZOLO(1,5-C)QUINAZOLIN-5-AMINE
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine
9-Chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine
9-CHLORO-2-(2-FURANYL)-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE
[1,2,4]Triazolo[1,5-c]quinazolin-5-amine,9-chloro-2-(2-furanyl)-
9-Chloro-5,6-dihydro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-imine | [Molecular Formula]
C13H8ClN5O | [MDL Number]
MFCD01529897 | [MOL File]
104615-18-1.mol | [Molecular Weight]
285.69 |
| Chemical Properties | Back Directory | [Melting point ]
278-279 °C | [density ]
1.72±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: >16 mg/mL
| [form ]
solid
| [pka]
1.23±0.30(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Uses]
Potent adenosine receptor antagonist | [Definition]
ChEBI: A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosi
e A2A receptors. | [Synthesis Reference(s)]
Journal of Heterocyclic Chemistry, 27, p. 1549, 1990 DOI: 10.1002/jhet.5570270605 | [Biological Activity]
Potent adenosine receptor antagonist (K i values are 3.5, 4.2, 16 and 51 nM for human A 1 , A 2A , A 2B and A 3 receptors respectively). Orally active in vivo . | [Biochem/physiol Actions]
CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity. | [storage]
Store at RT |
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