| Identification | Back Directory | [Name]
4-METHOXYPHENYL ISOCYANIDE | [CAS]
10349-38-9 | [Synonyms]
HANSA ISN-0053
4-Isocyanoanisole
Anisyl isonitrile
p-Anisyl isocyanide
p-Anisyl isonitrile
p-Anisoleisonitrile
P-ANISOYL ISONITRILE
p-Methoxyphenyl isocyanide
4-METHOXYPHENYL ISOCYANIDE
1-ISOCYANO-4-METHOXYBENZENE
4-Methoxyphenyl isocyanide 97%
benzene, 1-isocyano-4-methoxy-
Benzene, 1-isocyano-4-methoxy- (9CI) | [Molecular Formula]
C8H7NO | [MDL Number]
MFCD02664592 | [MOL File]
10349-38-9.mol | [Molecular Weight]
133.15 |
| Questions And Answer(Q&A) | Back Directory | [Preparation]
To an ice-cooled flask containing a solution of 10.5 gm (0.065 mole) of p-methoxyformanilide in 37.1 gm (0.47 mole) of pyridine and 13.0 ml (0.16 mole) of chloroform is added dropwise at 0°C 6.12 gm (0.040 mole) of phosphorus oxychloride. The solution is stirred for 1? hr at room temperature and then added to 55 ml of ice-water. The water layer is extracted with two 10-ml portions of chloroform; the combined chloroform layer is dried and distilled under reduced pressure, to afford 3.5 gm (40%), b.p. 767C (1.0 mm Hg), IR 2137 c m " 1 (R—NC).
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| Hazard Information | Back Directory | [Uses]
4-Methoxyphenyl isocyanide can be used to synthesize N-(isoquinolin-1-yl)-formamides via reaction with 2-alkynylbenzaldoximes in the presence of silver trifluoromethanesulfonate and bismuth triflate. | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 38, p. 2955, 1995 DOI: 10.1021/jm00015a018 |
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