| Identification | Back Directory | [Name]
(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat | [CAS]
1033805-28-5 | [Synonyms]
LX-1033
LP 778902
EOS-61310
Telotristat
Telotrisalt
Telotristat, LP778902
LP-778902/ Telotristat
LP778902;LP 778902;LP-778902
4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine
L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-
(S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoicacid
(2S)-2-Amino-3-[4-[2-amino-6-[[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethyl]oxy]pyrimidin-4-yl]phenyl]propionic acid
(2S)-2-aMino-3-[4-[2-aMino-6-[(1R)-1-[4-chloro-2-(3-Methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]pyriMidin-4-yl]phenyl]propanoic acid, Telotristat | [Molecular Formula]
C25H22ClF3N6O3 | [MDL Number]
MFCD20528907 | [MOL File]
1033805-28-5.mol | [Molecular Weight]
546.93 |
| Chemical Properties | Back Directory | [Boiling point ]
731.1±70.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
≥27.35 mg/mL in DMSO with ultrasonic; insoluble in H2O; insoluble in EtOH | [form ]
Powder | [pka]
2.04±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Definition]
ChEBI: Telotristat is a phenylalanine derivative. | [Biological Activity]
telotristat is the active metabolite of lx1606(telotristat etiprate), which is an orally bioavailable, small-molecule, tryptophan hydroxylase (tph) inhibitor with potential antiserotonergic activity. | [in vivo]
Telotristat etiprate is present in very low levels after oral administration. These low levels are due to rapid hydrolysis into the active moiety telotristat. The half-life ranges from approximately 4-12 h. There is no accumulation of telotristat with multiple dose administration over 2 weeks. Exposure to telotristat is approximately dose proportional[1]. |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|