| Identification | Back Directory | [Name]
N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER | [CAS]
103041-38-9 | [Synonyms]
3-(Pyridin-2-ylamino)propanoate
Dabigatran Etexilate Impurity 90
Ethyl 3-(pyridin-2-ylamino)propan
N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER
N-2-pyridinyl-β-Alanine,ethylester
Ethyl 3-(2-PyridylaMino)propanoate
Dabigatran Etexilate Intermdiate 4
Ethyl 3-(2-Pyridylamino)propionate
N-2-Pyridinyl-b-alanine ethyl ester
N-2-Pyridyl-beta-alanin ethyl ester
ethyl 3-(pyridin-2-ylamino)propanoate
Ethyl-3-(pyridin-2yl-Amino)propionate
N-2-pyridinyl-, ethyl ester
Alanine
β-Alanine, N-2-pyridinyl-, ethyl ester
N-2-Pyridinyl-beta-alanine ethyl ester
Ethyl-3-(pyridine-2-ylamino)propanoate
N-Ethyl 3-(pyridin-2-ylaMino)propanoate
N-Pyridin-2-yl-beta-alanine ethyl ester
N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER USP/EP/BP
3-(2-Pyridylamino)propionic Acid Ethyl Ester
ethyl (2R)-2-[(pyridin-2-yl)amino]propanoate
ethyl (2S)-2-[(pyridin-2-yl)aMino]propanoate
3-(Pyridin-2-ylaMino)-propionic acid ethyl ester | [EINECS(EC#)]
600-382-4 | [Molecular Formula]
C10H14N2O2 | [MDL Number]
MFCD09833621 | [MOL File]
103041-38-9.mol | [Molecular Weight]
194.23 |
| Chemical Properties | Back Directory | [Melting point ]
48-50°C | [Boiling point ]
125°C/0.2mmHg(lit.) | [density ]
1.131±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO, Methanol | [form ]
Solid | [pka]
6.26±0.10(Predicted) | [color ]
White | [InChI]
InChI=1S/C10H14N2O2/c1-2-14-10(13)6-8-12-9-5-3-4-7-11-9/h3-5,7H,2,6,8H2,1H3,(H,11,12) | [InChIKey]
UITNIDFEANEWPC-UHFFFAOYSA-N | [SMILES]
C(OCC)(=O)CCNC1C=CC=CN=1 | [LogP]
1.54 at 22℃ and pH6 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Dabigatran etexilate intermediate | [Uses]
Ethyl 3-(2-Pyridylamino)propanoate is an intermediate used in the synthesis of Dabigatran etexilate, as thrombin inhibitors. Ethyl Ester form of P993315.
| [Synthesis]
A method for preparing Ethyl 3-(pyridin-2-ylamino)propanoate comprises the following steps: using 2-aminopyridine and ethyl acrylate as raw materials, using anhydrous ethanol as a solvent, using trifluoromethanesulfonic acid as a catalyst, and heating in an oil bath to control the temperature at 120 to 160° C. for a catalytic reaction for 16 to 20 hours under nitrogen protection. The obtained reaction solution is washed with petroleum ether at a temperature of 35 to 40° C. and a pressure of 0.09 to 0.1 MPa, then concentrated under reduced pressure, and then washed with petroleum ether/ethyl acetate and recrystallized to obtain white flaky crystals of Ethyl 3-(pyridin-2-ylamino)propanoate. |
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