| Identification | Back Directory | [Name]
HuangjiangSu A | [CAS]
1026020-27-8 | [Synonyms]
HuangjiangSu A
β-D-Glucopyranoside, (3β,25R)-26-(β-D-glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-
(3beta,25R)-26-(beta-D-Glucopyranosyloxy)furosta-5,20(22)-dien-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-[beta-D-glucopyranosyl-(1-4)]-beta-D-glucopyranoside | [Molecular Formula]
C51H82O22 | [MDL Number]
MFCD34469187 | [MOL File]
1026020-27-8.mol | [Molecular Weight]
1047.2 |
| Chemical Properties | Back Directory | [Melting point ]
274-276 °C | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12?+-.0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
Huangjiangsu A is a natural active ingredient found in many plants such as Dioscorea villosa and Polygonatum multiflorum. It belongs to the steroidal saponin class of compounds. Huangjiangsu A is not cytotoxic, and treatment of HepG2 cells with it prior to exposure to H2O2 was effective in increasing cell viability in a concentration-dependent manner. In addition, 50 μM of Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin increased GSH levels and reduced intracellular ROS production, thereby counteracting H2O2-induced injury. Thus, Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation, and is expected to be a potential drug for the treatment of liver diseases[1-2]. | [Uses]
Huangjiangsu A, pseudoprotodioscin, methyl protobioside, protodioscin, and protodeltonin, isolated from D. villosa.
Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation and could be promising as potential therapeutic agents for liver diseases[1]. | [References]
[1] MAQSOOD A SIDDIQUI. Hepatoprotective Effect of Steroidal Glycosides From Dioscorea villosa on Hydrogen Peroxide-Induced Hepatotoxicity in HepG2 Cells.[J]. Frontiers in Pharmacology, 2018. DOI:10.3389/fphar.2018.00797.
[2] LILI GVAZAVA . New furostanol glycosides from Polygonatum multiflorum (L.) All.[J]. Natural Product Research, 2019. DOI:10.1080/14786419.2018.1431628.
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