| Identification | Back Directory | [Name]
Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)- | [CAS]
102293-80-1 | [Synonyms]
BNKY020-VT01
Albuterol sulfate iMpurit 2
6-Bromoacetyl-2,2-dimethyl-4H-benzo[1,3]dioxine
2,2-Dimethyl-6-(bromoacetyl)-4H-1,3-benzodioxin
2-BROMO-1-(2,2-DIMETHYL-4H-1,3-BENZODIOXIN-6-YL)ETHANONE
2-Bromo-1-(2,2-dimethyl-4H-1,3-benzadioxin-6-yl) ethanone
2-Bromo-1-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-ethanone
Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-
2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone
TIANFU CHEM---Ethanone, 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-
Vilanterol Impurity 8Q: What is
Vilanterol Impurity 8 Q: What is the CAS Number of
Vilanterol Impurity 8 | [Molecular Formula]
C12H13BrO3 | [MDL Number]
MFCD26385854 | [MOL File]
102293-80-1.mol | [Molecular Weight]
285.13 |
| Hazard Information | Back Directory | [Synthesis]
At about -78° C., sodium bis(trimethylsilyl)amide in tetrahydrofuran (1.0M) (2.9 mL) was added to a solution of 1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone (500 mg; 2.43 mmol; 1.00 equiv) in tetrahydrofuran (20 mL). The solution was stirred at about -78° C. for about 1 hour, and chlorotrimethylsilane (290 mg, 2.64 mmol, 1.09 equiv, 99%) was added. The solution was stirred at about -78° C. for about 30 min, and then bromine (390 mg; 2.41 mmol; 0.99 equiv) was added. The solution was stirred at about -78° C. for about 1 hour, and then an aqueous solution of 5% sodium sulfite and 5% sodium bicarbonate (50 mL) was added. Following standard extractive workup with ethyl acetate, the crude residue was then purified by silica gel column chromotagraphy with ethyl acetate/petroleum ether (1/12) to give the title product as a pale yellow oil 2-Bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanone (400 mg; 57% yield).
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