| Identification | Back Directory | [Name]
S0859 | [CAS]
1019331-10-2 | [Synonyms]
S0859
100852
CS-1766
S0859, >98%
S0859 >=98% (HPLC)
S 0859; S-0859; S 0859; S-0859
(4S)-4-HYDROXY-4-[(3R)-3-HYDROXYBUTYL]-3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-ONE
2-Chloro-N-({4-[2-(cyanosulfamoyl)phenyl]phenyl}methyl)-N-[(4-methylphenyl)methyl]benzamide
2-Chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide
2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]- S0859
2-Chloro-N-[[2′-[(cyanoamino)sulfonyl][1,1′-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]-benzamide
Benzamide, 2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]- | [Molecular Formula]
C29H24ClN3O3S | [MDL Number]
MFCD23136018 | [MOL File]
1019331-10-2.mol | [Molecular Weight]
530.04 |
| Questions And Answer | Back Directory | [Uses]
2-Chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]benzamide is a selective inhibitor of sodium-bicarbonate cotransporters in mammalian heart. |
| Hazard Information | Back Directory | [Description]
S0859 is an N-cyanosulphonamide that blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7), which regulates intracellular pH, particularly in myocytes.1 It inhibits intracellular pH recovery in myocytes with a Ki value of 1.7 μM, with full inhibition occurring at ~30 μM.1 S0859 does not affect other exchange proteins or enzymes that might regulate intracellular pH. It prevents changes in pH associated with depolarization and hyperpolarization of ventricular myocytes from rabbit, rat, and guinea pig.2 S0859 has also been used to study the role of NBC in coronary endothelial cells, cancer cells, embryonic kidney cells, and neutrophils.3,4,5,6 | [Biochem/physiol Actions]
S0859 is a selective high-affinity generic inhibitor of the Na+/HCO3- sodium bicarbonate co-transporter (NBC). S0859 does not inhibit Na+-H+ exchange (NHE). | [storage]
Store at -20°C |
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| Company Name: |
ChemShuttle, Inc.
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| Tel: |
0510-83588313-802 18800520310; |
| Website: |
https://www.jiehuapharma.com/ |
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