| Identification | Back Directory | [Name]
REV 5901 | [CAS]
101910-24-1 | [Synonyms]
PF-5901
RG-5901
RG-5901A
REV 5901
1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol
2-[3-(1-Hydroxyhexyl)phenoxymethyl]quinoline
α-pentyl-3-[2-quinolinylmethoxy]benzyl alcohol
ALPHA-PENTYL-3-[2-QUINOLINYLMETHOXY]BENZYL ALCOHOL
Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-
3-[(Quinolin-2-yl)methoxy]-α-pentylbenzenemethanol
ALPHA-PENTYL-3-(2-QUINOLINYLMETHOXY)-BENZENEMETHANOL | [Molecular Formula]
C22H25NO2 | [MOL File]
101910-24-1.mol | [Molecular Weight]
335.44 |
| Chemical Properties | Back Directory | [Boiling point ]
497.7±35.0 °C(Predicted) | [density ]
1.123±0.06 g/cm3(Predicted) | [storage temp. ]
Room temperature | [solubility ]
≤100mg/ml in ethanol;100mg/ml in methanol;100mg/ml in acetone;100mg/ml in DMSO;100mg/ml in etonitrile. | [form ]
Off-white to tan solid. | [pka]
14.48±0.20(Predicted) | [color ]
white to yellow-brown |
| Hazard Information | Back Directory | [Description]
REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 μM. | [Uses]
L-655,238 is a potent and selective inhibitor of FLAP (5-LO-activating protein). | [Uses]
REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 μM. | [Definition]
ChEBI: 1-[3-(2-quinolinylmethoxy)phenyl]-1-hexanol is a member of quinolines. | [in vitro]
previous in-vitro showed that rev 5901 had a ki value of 0.7 μm vs. [3h]leukotriene d4 ([3h]-ltd4) binding to membranes from guinea pig lung. against ltc4-, ltd4- and lte4-induced contractions of guinea pig parenchymal strips, rev 5901 had kb values of ca 3 μm and was relatively ineffective against contractions that was induced by other spasmogens. moreover, in isolated guinea pig hearts, the peptiodoleukotriene-antagonist activity was also observed against the hemodynamic and vasoconstriction effects of ltd4. in addition, unlike other reported antagonists, rev 5901 was found to be ineffective against the multiple forms of cyclic nucleotide phosphodiesterases [1]. | [in vivo]
animal study found that the oral antagonist activity had been shown with an ltd4-induced bronchoconstriction model and with an ltd4-induced wheal response model in guinea pigs [1]. | [storage]
Room temperature | [References]
[1] van inwegen, r. g.,khandwala, a.,gordon, r., et al. rev 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile. journal of pharmacology and experimental therapeutics 241, 117-124 (1987). |
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BOC Sciences
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https://www.bocsci.com |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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Merck KGaA
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(+86) 21 2033 8288 |
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http://www.sigmaaldrich.cn |
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