| Identification | Back Directory | [Name]
Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI) | [CAS]
101714-41-4 | [Synonyms]
BIX
BiP inducer X
BIX >=98% (HPLC)
BiP protein Inducer X
Thiocyanic acid 3,4-dihydroxyphenacyl ester
2-(Cyanosulfanyl)-1-(3,4-dihydroxyphenyl)ethan-1-one
2-(3,4-Dihydroxyphenyl)-2-oxoethyl ester thiocyanic acid
Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester
Thiocyanic acid, 2-(3,4-dihydroxyphenyl)-2-oxoethyl ester (9CI)
GRP78,Apoptosis,BiP,Inhibitor,inhibit,GRP94,BiP inducer X,stress,neurons,calreticulin | [Molecular Formula]
C9H7NO3S | [MDL Number]
MFCD22415334 | [MOL File]
101714-41-4.mol | [Molecular Weight]
209.22 |
| Chemical Properties | Back Directory | [Boiling point ]
517℃ | [density ]
1.476 | [Fp ]
267℃ | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
BIX has been used in cell viability assay. | [Definition]
ChEBI: 2-(3,4-dihydroxyphenyl)-2-oxoethyl thiocyanate is a member of the class of thiocyanates that is 3,4-dihydroxyacetophenone in which one of the methyl hydrogens has been replaced by the sulfur of a cyanosulfanediyl (-SC#N) group. It has been found to induce the expression of the endoplasmic reticulum chaperone protein GRP78 (78 kDa glucose-regulated protein, BiP, a highly conserved member of the 70 kDa heat shock protein family) leading to an attenuation of the unfolded protein response. It protects neuronal cells and retinal cells from endoplasmic reticulum (ER)-stress induced cell death. It is a member of thiocyanates, an aromatic ketone and a member of catechols. | [Biochem/physiol Actions]
BIX (BiP protein inducer X) induces the expression of the endoplasmic reticulum chaperone protein GRP78 (glucose regulated protein 78, BiP) leading to an attenuation of the unfolded protein response. BIX protects neuronal cells and retinal cells from ER-stress induced cell death. | [storage]
Store at -20°C |
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